Biochem/physiol Actions

Reversible: yes

Primary TargetA1

General description

A potent and selective agonist of adenosine A1 receptor (A1R) (K_i = 2.3 nM, 790 nM, 18.6 µM, 43nM for human A1, A2A, A2B, and A3, respectively).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Migita, H., et al. 2008. J Neurosci Res.86, 2820.Burgdorf, C. et al. 2005. J Cardiovasc Pharmacol.45, 1.Klotz, K. N., et al. 2000. Naunyn Schmiedebergs Arch Pharmacol. 362, 382.Mironov, S., et al. 1990. J Neurophysiol.81, 1.Monopoli, A., et al. 1994. Arzneimittelforschung.44, 1305.Concas, A., et al. 1993. J Pharmacol Exp Ther.267, 844.Lohse, M. J., et al. 1988. Nauryn Schmiedebergs Arch Pharmacol.337, 687.Coffin, V. L., et al. 1987. J Pharmacol Exp Ther.241, 76.

Packaging

25 mg in Glass bottle

Preparation Note

slight warming is required for complete solubilization in ethanol

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)